Goal
The CARES Study seeks to adapt the Comprehensive Adherence Resource and Empowerment Support (CARES) intervention to support adolescent girls and young women (AGYW) aged 16–24 in Zimbabwe to effectively use oral, ring, and injectable PrEP. The project is funded by the National Institute of Mental Health (NIMH).
The specific aims are:
- Adapt CARES for real-world delivery to improve PrEP adherence.
- Test its effectiveness in increasing continuation and adherence to PrEP.
- Evaluate feasibility, acceptability, and fidelity of CARES in routine health settings.
Study Description
The study uses a formative, qualitative research approach, including focus group discussions, key informant interviews, and adaptation workshops. It involves co-designing an adherence intervention with AGYW, providers, policymakers, and funders, to modify CARES for public health contexts and ensure sustainable HIV prevention support. Study duration: 1.5 years, with enrolment and accrual lasting 3–8 months.
Target Population
- Adolescent girls and young women aged 16–24 years (including emancipated minors).
- Key informants: PrEP providers, clinic and program leaders, policymakers, and funding agency representatives.
Geographic Location
The study is conducted in Zimbabwe at:
- The SHAZ! Hub in Chitungwiza
- Cowdray Park Clinic in Bulawayo
Results
Aim 1: Formative phase study
Study outcomes include:
- 12 Key Informant Interviews (KII)
- 48–72 AGYW enrolled in focus groups
- Workshops with youth experts, providers, and policymakers
Outcomes will include adapted intervention materials (counseling manuals, SOPs, job aids, and monitoring tools), rather than direct health service delivery at this stage.
AIM 2: Observation and Intervention phase
Study outcomes will include:
Number of AGYW on PrEP
Number of AGYW receiving adherence support